Correlation Analysis of Gene and Radiomic Features in Colorectal Cancer Liver Metastases

Table 2

Function enrichment of subnetworks identified by MCODE.

Subnet number	Function annotation number	Function annotation description
MCODE_1	R-HSA-373076	Class A/1 (rhodopsin-like receptors)	-27.0
MCODE_1	R-HSA-375276	Peptide ligand-binding receptors	-26.9
MCODE_1	R-HSA-418594	G alpha (i) signaling events	-25.8
MCODE_2	GO:0051770	Positive regulation of nitric-oxide synthase biosynthetic process	-10.5
MCODE_2	CORUM:7385	DTX3L-PARP9-STAT1 complex	-10.2
MCODE_2	GO:0071346	Cellular response to interferon-gamma	-10.2
MCODE_3	Ko05323	Rheumatoid arthritis	-9.6
MCODE_3	Hsa05323	Rheumatoid arthritis	-9.4
MCODE_3	ko04514	Cell adhesion molecules (CAMs)	-8.6
MCODE_4	GO:0002757	Immune response-activating signal transduction	-3.6
MCODE_4	GO:0002764	Immune response-regulating signaling pathway	-3.5
MCODE_4	GO:0002253	Activation of immune response	-3.5
MCODE_5	R-HSA-389948	PD-1 signaling	-15.6
MCODE_5	R-HSA-388841	Costimulation by the CD28 family	-13.1
MCODE_5	Hsa04514	Cell adhesion molecules	-11.4
MCODE_7	GO:0002479	Hallmark coagulation	-7.7
MCODE_7	GO:0042590	Complement cascade	-7.6
MCODE_7	R-HSA-1236974	ER-phagosome pathway	-7.6