Research Article
A Rule-Based Inference Framework to Explore and Explain the Biological Related Mechanisms of Potential Drug-Drug Interactions
Table 1
Summary of the potential mechanism of interaction of coadministered irinotecan and levofloxacin.
| | Irinotecan | Levofloxacin |
| | Pharmacological effects | | Metabolizing enzymes | CYP3A4 substrate | CYP3A4 inhibitor | | Transporters | ABCB1 substrate | ABCB1 inhibitor | | Biomedical features | | Pharmacological (MoA) | NA | NA | | Biomolecular | NA | NA | | Physiological | Decreased DNA integrity | | Genetic | NA | NA |
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