Study (year) Country Age (E/C) Sample (E/C) Interventions (E/C) Follow-up (week) Outcomes Chappity et al. (2014) [14 ] India 36.9 117/117 Omeprazole 20 mg (2 times/d)/lifestyle change treatment only 12 ② Shaheen et al. (2010) [15 ] United States 22/18 Esomeprazole 40 mg (2 times/d)/placebo 12 ①③④⑥ Fass et al. (2009) [16 ] United States 24/17 Esomeprazole 20 mg (2 times/d)/placebo 12 ②④⑤ Lam et al. (2010) [17 ] China 42/40 Rabeprazole 20 mg (2 times/d)/placebo 12 ①③④⑤ Reichel et al. (2008) [18 ] United Kingdom 30/28 Esomeprazole 20 mg (2 times/d)/placebo 12 ①③④⑤ Wo et al. (2005) [19 ] United States 39/37 20/19 Pantoprazole 40 mg(1 time/d)/placebo 12 ② Vaezi et al. (2006) [20 ] Australia 95/50 Esomeprazole 40 mg (2 times/d)/placebo 16 ②⑥ Eherer et al. (2003) [21 ] United States 48 10/10 Pantoprazole 40 mg (2 times/d)/placebo 12 ②⑥ Steward et al. (2004) [22 ] United States 21/21 Rabeprazole 20 mg (2 times/d)/placebo 8 ①②③④⑤ El-Serag et al. (2001) [23 ] United States 59/65 12/10 Lansoprazole 30 mg (2 times/d)/placebo 12 ② Noordzij et al. (2001) [24 ] United States 51.7/45.3 15/15 Omeprazole 40 mg (2 times/d)/placebo 8 ②④⑤ Ours et al. (1999) [25 ] United States 54 8/9 Omeprazole 40 mg (2 times/d)/placebo 12 ② Langevin and Ngo (2001) [26 ] Canada 53 14/16 Omeprazole 40 mg (2 times/d)/placebo 12 ② Rabeneck et al. (1999) [27 ] Australia 54 8/7 Lansoprazole 30 mg (2 times/d)/placebo 12 ④
