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| Gene symbol | Score | Full name | Distribution |
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| SERPINE1 | 32 | Serpin family E member 1 | Serine protease inhibitor; plasminogen activator inhibitor 1. Tissue plasminogen activator, urokinase, protein C, and matriptase-3/TMPRSS7 are all attracted to this inhibitor. Its quick interaction with PLAT might be a crucial control point in fibrinolysis regulation. |
| THBS1 | 32 | Thrombospondin 1 | Cell-to-cell and cell-to-matrix adhesion glycoprotein thrombospondin-1 modulates cell-to-cell and cell-to-matrix connections. This chemical binds to heparin. Dentin and dental pulp dentinogenesis and/or maintenance may be affected (by similarity). A CD36 ligand is responsible for the antiangiogenic actions. It has a function in the ER stress response by interacting with the activating transcription factor 6 alpha (ATF6), which produces adaptive ER stress response factors (by similarity) |
| CCL2 | 30 | C-C motif chemokine ligand 2 | Chemotactic factor with a C-C motif, which attracts monocytes and basophils but not neutrophils or eosinophils. Increases the antitumor activity of monocytes. Has been linked to the development of disorders with monocytic infiltrates, such as psoriasis, rheumatoid arthritis, and atherosclerosis. During the disease process of atherosclerosis, it may be implicated in the recruitment of monocytes into the artery wall. |
| MMP7 | 30 | Matrix metallopeptidase 7 | Matrilysin degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase; M10 matrix metallopeptidases |
| CXCL8 | 30 | C-X-C motif chemokine ligand 8 | IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T cells but not monocytes. It has a role in neutrophil activation as well. In response to an inflammatory stimulation, it is secreted by a variety of cell types. When compared to IL-8 (1-77), IL-8 (6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8 (5-77) has enhanced activity on neutrophil activation, and IL-8 (7-77) has a stronger affinity to CXCR1 and CXCR2 receptors. |
| EPCAM | 28 | Epithelial cell adhesion molecule | Intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) establish a physical homophilic contact molecule at the mucosal epithelium to build an immunological barrier as a first line of defence against mucosal infection. Plays a function in the proliferation and differentiation of embryonic stem cells. The expression of FABP5, MYC, and cyclins A and E is all increased. |
| VCAN | 24 | Versican | Intercellular signaling and cell-extracellular matrix interactions may be mediated by the Versican core protein. It might play a part in cell motility, proliferation, and differentiation. Has a C-type lectin domain that binds hyaluronic acid. |
| ITGA2 | 24 | Integrin subunit alpha 2 | Integrin alpha-2 (integrin alpha-2/beta-1) is a receptor for laminin, collagen, collagen C-propeptides, fibronectin, and E-cadherin. It recognises the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Platelet and other cell adhesion to collagens, collagen and collagenase gene expression control, force creation, and structuring of newly formed extracellular matrix are all mediated by CD molecules. |
| AREG | 24 | Amphiregulin | Amphiregulin is a ligand for the EGF receptor/EGFR. Amphiregulin is an amitogen and autocrine growth factor for a range of target cells, including astrocytes, Schwann cells, and fibroblasts. |
| HAS2 | 22 | Hyaluronan synthase 2 | Hyaluronan synthase 2 adds GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. As a result, it is essential for the formation of hyaluronan, a major component of most extracellular matrices that regulates cell adhesion, migration, and differentiation and plays a structural role in tissue architecture. This is one of the isozymes that catalyses the process and is responsible for the production of high-molecular-mass hyaluronan. A key phase in the creation of the heart is the conversion of endocardial cushion cells to mesenchymal cells. |
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