Research Article
[Retracted] DNMT1-Mediated DNA Methylation Targets CDKN2B to Promote the Repair of Retinal Ganglion Cells in Streptozotocin-Induced Mongolian Gerbils during Diabetic Retinopathy
Figure 5
DNMT1-mediated DNA methylation inhibited the expression of CDKN2B and facilitated RGC proliferation. (a) MTS assay was performed to compare the proliferation rates between NC (negative control) and DNMT1 siRNA-transfected RGCs. (b) RGCs were transfected with siDNMT1 or NC for 48 h and examined using flow cytometric analysis to determine the cell cycle phase distribution. (c) Quantification of the proliferation rates in siDNMT1+NC and siDNMT1+siCDKN2B-transfected RGCs using the MTS assay. (d) RGCs were cotransfected with siDNMT1+NC or siDNMT1+siCDKN2B for 48 h. Cells were analyzed by flow cytometry to determine the cell distribution at each phase of the cell cycle. , .
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