Prognostic Factors of Gliosarcoma in the Real World: A Retrospective Cohort Study

Table 1

Clinical characteristics of 45 GSM cases.

(a)

Characteristics	Number of patients ()	Proportion (%)
Relapse	30	66.7
Death	24	53.3
Age
Average age, years	53.2
Median age, years	56
<60	26	57.8
≥60	19	42.2
Sex
Male	32	71.1
Female	13	28.9
KPS
≤70	15	33.3
>70	30	66.7
Primary or secondary
Primary GSM	37	82.2
Secondary GSM	8	17.8
GBM-origined	5	11.1
Non-GBM-origined	3	6.6
Number of lesions
Single	44	97.8
Multiple	1	2.2
Size, diameter
≤3 cm	13	28.9
>3 cm	32	71.1
Location
Temporal	19	42.2
Frontal	12	26.7
Parietal	5	11.1
Basal ganglia	4	8.9
Callosum	3	6.7
Thalamus	1	2.2
Brainstem	1	2.2
Laterality
Left	20	44.4
Right	16	35.6
Profound	9	20.0
Epileptic seizure
No	40	88.9
Yes	5	11.1
Intracranial hypertension
No	9	20.0
Yes	36	80.0
Level of Ki-67
≤15%	15	33.3
>15%	30	66.7
Resection range
GTR	41	91.1
STR/NTR	4	8.9
Biopsy	0	0
Radiotherapy
No	11	24.4
Yes	33	73.3
Missing	1	2.2
Dose, mean (SD)	57.97 (2.75)
Concurrent TMZ
No	11	24.4
Yes	33	73.3
Missing	1	2.2
Adjuvant TMZ
No	12	26.7
Yes	32	71.1
Missing	1	2.2

(b)

Gene locus	Wild-type (%)	Mutated (%)	Missing
IDH1	40 (100.0)	0 (0.0)	5
p53	14 (33.3)	28 (66.7)	3
PTEN	5 (55.6)	4 (44.4)	36
MGMT	11 (64.7)	6 (35.3)	28
1p/19q codeletion	10 (66.7)	5 (33.3)	30
TERT	5 (27.8)	13 (72.2)	27
BRAF	19 (90.5)	2 (9.5)	24
PIK3CA	9 (81.8)	2 (18.2)	34
ATRX	8 (21.6)	29 (78.4)	8
EGFR	8 (80.0)	2 (20.0)	35