Prognostic Factors of Gliosarcoma in the Real World: A Retrospective Cohort Study

Table 2

Univariable and multivariable analysis according to OS and RFS.

(a)

Variable name	Univariable analysis, OS		Multivariable analysis, OS
	value	HR (95% CI)	value	HR (95% CI)
Age	0.732	1.151 (0.515-2.572)
Sex	0.358	0.678 (0.296-1.553)
Primary or secondary	0.749	0.850 (0.315-2.298)
Primary vs. GBM-origined	0.317	1.742 (0.588–5.166)
Primary vs. non-GBM-origined	0.507	0.503 (0.066-3.827)
KPS	0.847	0.919 (0.392–2.157)
Location	0.548
Frontal vs. deep	0.195	0.452 (0.136-1.500)
Parietal vs. deep	0.989	0.990 (0.244-4.024)
Temporal vs. deep	0.364	0.624 (0.226-1.728)
Size	0.334	0.657 (0.280-1.542)
Number of lesions	0.036	0.095 (0.011-0.853)
Epileptic seizure	0.684	0.739 (0.172-3.170)
Intracranial hypertension	0.377	0.639 (0.237-1.725)
Ki-67 level	0.132	2.039 (0.807-5.151)	0.059	2.803 (0.963-8.162)
Resection range	0.125	0.382 (0.111-1.306)	0.023	0.192 (0.046-0.797)
Radiotherapy	0.991	0.995 (0.389-2.546)
Concurrent TMZ	0.991	0.995 (0.389-2.546)
Adjuvant TMZ	0.742	0.860 (0.351-2.110)
Gene mutation
IDH1	—	—
p53	0.807	0.893 (0.360-2.216)
PTEN	0.809	1.221 (0.243-6.122)
MGMT	0.953	0.950 (0.173-5.229)
1p/19q codeletion	0.381	2.057 (0.410-10.318)
TERT	0.209	47.014 (0.116-18994)
BRAF	0.288	2.436 (0.472-12.569)
PIK3CA	0.483	2.262 (0.232-22.095)
ATRX	0.165	0.483 (0.173-1.349)
EGFR	0.975	0.966 (0.111-8.415)

(b)

Variable name	Univariable analysis, RFS		Multivariable analysis, RFS
	value	HR (95% CI)	value	HR (95% CI)
Age	0.700	1.171 (0.524-2.616)
Sex	0.568	0.784 (0.341-1.805)
Primary or secondary	0.715	1.202 (0.448-3.228)
Primary vs. GBM-origined	0.417	1.566 (0.529-4.636)
Primary vs. non-GBM-origined	0.646	0.624 (0.083-4.684)
KPS	0.800	0.896 (0.383-2.096)
Location	0.708
Frontal vs. deep	0.367	0.578 (0.176-1.900)
Parietal vs. deep	0.995	1.004 (0.250-4.041)
Temporal vs. deep	0.424	0.660 (0.238-1.831)
Size	0.426	0.706 (0.300-1.663)
Number of lesions	0.022	0.071 (0.007-0.679)
Epileptic seizure	0.857	0.875 (0.205-3.731)
Intracranial hypertension	0.513	0.714 (0.260-1.958)
Ki-67 level	0.130	2.066 (0.809-5.278)	0.052	2.996 (0.992-9.053)
Resection range	0.137	0.395 (0.116-1.345)	0.022	0.181 (0.042-0.782)
Radiotherapy	0.861	0.919 (0.360-2.348)
Concurrent TMZ	0.861	0.919 (0.360-2.348)
Adjuvant TMZ	0.631	0.804 (0.330-1.959)
Gene mutation
IDH1	—	—
p53	0.995	0.997 (0.402-2.474)
PTEN	0.745	1.307 (0.261-6.550)
MGMT	0.992	1.009 (0.184-5.527)
1p/19q codeletion	0.433	1.900 (0.382-9.440)
TERT	0.202	49.123 (0.125-19.370)
BRAF	0.270	2.529 (0.487-13.134)
PIK3CA	0.838	1.252 (0.145-10.817)
ATRX	0.298	0.581 (0.209-1.617)
EGFR	0.951	1.070 (0.124-9.249)