Gadoxetic Acid-Enhanced MRI-Based Radiomics Signature: A Potential Imaging Biomarker for Identifying Cytokeratin 19-Positive Hepatocellular Carcinoma

Figure 1

Radiomics workflow for CK19 status prediction in hepatocellular carcinoma. The workflow consists of five key steps. Step 1: after acquisition of preoperative MRI images, tumor segmentation was performed by using ITK-SNAP software. Step 2: radiomics features were extracted from the delineated tumor on the three phases (arterial phase, portal venous phase, and hepatobiliary phase). Step 3: top 10 reproducible and informative features were selected by inter-/intraclass agreement analysis, correlation analysis, and the recursive feature elimination. Step 4: the selected features were subjected to logistic regression analysis to construct the prediction models. Step 5: the model performance was evaluated by the area under the curve.