DAB2IP Stabilizes p27^Kip1 via Suppressing PI3K/AKT Signaling in Clear Cell Renal Cell Carcinoma

Figure 2

Loss of DAB2IP enhances ccRCC growth by suppressing p27. (a) Western blotting of control (Con), DAB2IP knockdown (KD) cells, and KD cells transfected with different amounts of DAB2IP cDNA. (b) Cell cycle assay of Caki-2 Con and KD cells and 786-O Con and KD cells. (c) Cell proliferation of Con and KD cells cultured in 0.5% FBS medium. Subcutaneous xenografts of 786-O Con and KD cells were established, (d) tumor growth curve and (e) tumor weight at the end of experiment were shown. (f) IHC staining of p27 and Ki-67 in 786-O Con and KD tumor tissues. Scale bar, 200 μm; .

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