Computational and Mathematical Methods in Medicine / 2023 / Article / Tab 3 / Research Article
Combined Network Pharmacology and Molecular Docking to Verify the Treatment of Type 2 Diabetes with Pueraria Lobata Radix and Salviae Miltiorrhizae Radix Table 3 Corresponding core targets genes of main ingredient based on the degree value.
Gene name Degree Betweenness centrality Closeness centrality AKT1 26 0.09722044 0.93333333 VEGFA 25 0.08297252 0.90322581 NOS3 24 0.0748313 0.875 PPARG 22 0.06089927 0.82352941 MMP9 22 0.04616644 0.82352941 VCAM1 20 0.04275445 0.77777778 CAT 20 0.0317474 0.77777778 STAT3 19 0.0224157 0.75675676 IL4 18 0.02462019 0.73684211 HIF1A 16 0.00700457 0.7 CTNNB1 16 0.01164871 0.7 ESR1 15 0.01381435 0.68292683 TGFB1 15 0.0043485 0.68292683 SIRT1 14 0.00583073 0.66666667 GPT 13 0.00790826 0.65116279 NOS2 13 0.00240188 0.65116279 SOD1 10 0.00254587 0.60869565 AGTR1 10 0.00472411 0.60869565 DPP4 10 0.00459492 0.60869565 AR 9 0.00176367 0.58333333 SELP 9 0.00262661 0.59574468 CD40LG 7 0 0.57142857 AKR1B1 7 7.94E-04 0.57142857 ACE2 7 6.42E-04 0.57142857 CYP19A1 6 5.93E-04 0.56 LEPR 6 1.89E-04 0.56 PLAT 5 0 0.54901961 PON1 5 2.04E-04 0.53846154 ADRB2 5 2.94E-04 0.54901961
