Selective Phenome Growth Adapted Model: A Novel Landscape to Represent Aptamer Ligand Binding

Figure 5

Comparison of numbers of phenotypic contributors for interaction map: (a) comparison of examples of interaction map relative dimensions. (b) Comparison of basin sizes by accessibility of local optima. For each of the four interaction maps 100,000 adaptive walks were used to discover the accessibility of the fitness landscape’s local optima. (c) Comparison of hamming distances from fittest optima. For each of the four interaction maps 100,000 adaptive walks were used to discover optima and the hamming distance of the fittest optima to all other optima versus optima fitness plotted. The four interaction maps compared are (i) 46 phenotypic contributors, (ii) 76 phenotypic contributors, (iii) 96 phenotypic contributors, and (iv) 136 phenotypic contributors.

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