|
| Study | Modality | Subjects | Node definition | Edge definition | Network type | Main findings |
|
| Supekar et al., 2008 [88] | fMRI | 21 AD
18 HC | 90 regions in AAL atlas | Wavelet correlation | Weighted | (1) Compared with HC, the loss of small-world property characterized by a lower clustering coefficient in AD in low frequency band: 0.01–0.05 Hz.
(2) Lower clustering coefficients in the left and right hippocampus in AD. |
|
| Wang et al., 2013 [89] | fMRI | 37 aMCI
47 HC | 1024 regions in H-1024 [102] | Wavelet correlation | Weighted | (1) Decreased functional connectivity in the frequency band, 0.031–0.063 Hz, in aMCI.
(2) Increased path length in aMCI. |
|
| Brier et al., 2014 [85] | fMRI | 31
CDR 1
90
CDR 0.5
205
CDR 0 | 160 regions [61] | Pearson correlation | Binary | (1) Reduced clustering coefficient and modularity with increasing CDR.
(2) No significant differences in path length among participants with different CDR. |
|
| Golbabaei et al., 2016 [86] | fMRI | 21 AD
21 HC | 90 regions in AAL atlas | Pearson correlation | Weighted | (1) Decreased clustering coefficient and global efficiency and increased characteristic path length in AD.
(2) Decreased node strength, local clustering coefficient, and local efficiency and increased local characteristic path length in olfactory, hippocampus, parahippocampal, amygdala, and superior parietal gyrus in AD. |
|
| Buldú et al., 2011 [34] | MEG | 19 AD
19 HC | 148 sensors | Synchronization likelihood | Weighted | (1) Higher connection strength in MCI.
(2) Lower normalized clustering coefficient and characteristic path length in MCI. |
|
| de Haan et al., 2012 [21] | MEG | 18 AD
18 HC | 149 channels | Synchronization likelihood | Weighted | (1) Loss of network connectivity and altered synchronizability in most frequency bands in AD.
(2) Low centrality of the left temporal region in the theta band in AD. |
|
| Engels et al., 2015 [103] | EEG | 117
se-AD
96
mo-AD
105
mi-AD
133 HC | 21 channels | Phase lag index | Weighted | (1) Decreased functional connectivity with increasing AD severity in the alpha band.
(2) Increased betweenness centrality with increasing AD severity in all regions (except for posterior).
(3) Decreased hub regions in posterior regions and increased hub regions in most anterior regions with increasing AD severity. |
|
| Deng et al., 2016 [104] | EEG | 30 AD
35 LMCI
52 EMCI
44 HC | 25 regions | Wavelet correlation | Binary | (1) Increased clustering coefficient and longer characteristic path length in AD compared with HC.
(2) No significant difference of clustering coefficient and characteristic path length between EMCI and HC and between LMCI and HC. |
|
