Robust-Output-Controlled Synchronization Strategy for Arrays of Pancreatic <i>β</i>-Cells

<div>States of the reference <i>β</i>-cell <svg height="11.927pt" id="M255" style="vertical-align:-3.291101pt" version="1.1" viewbox="-0.0498162 -8.6359 12.3012 11.927" width="12.3012pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M570 168L541 175C510 88 481 71 415 71H135L378 358L167 614H348C422 614 447 608 463 588C478 571 488 546 500 500L529 504C524 559 519 633 518 650H47V628L295 324L33 23V0H531L570 168Z"></path></g><g transform="matrix(.0091,0,0,-0.0091,7.774,3.132)"><path d="M397 380C406 395 404 411 396 425S369 451 350 451C302 451 239 372 192 294H189L199 338C214 407 207 451 180 451C152 451 83 405 30 345L48 318C87 354 117 372 125 372S135 362 127 324L55 -5L61 -12C87 -5 117 3 139 5C154 87 168 162 179 207C198 250 240 310 260 332C281 355 297 366 307 366C321 366 333 360 347 346C351 342 360 342 369 348C379 355 389 366 397 380Z"></path></g></svg> and the <i>β</i>-cells in the islet <span class="nowrap"><svg height="11.927pt" id="M256" style="vertical-align:-3.291101pt" version="1.1" viewbox="-0.0498162 -8.6359 10.9584 11.927" width="10.9584pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M570 168L541 175C510 88 481 71 415 71H135L378 358L167 614H348C422 614 447 608 463 588C478 571 488 546 500 500L529 504C524 559 519 633 518 650H47V628L295 324L33 23V0H531L570 168Z"></path></g><g transform="matrix(.0091,0,0,-0.0091,7.774,3.132)"><path d="M250 606C250 634 233 656 203 656C168 656 146 618 146 593C146 564 169 545 192 545C227 545 250 573 250 606ZM227 95L212 119C187 98 152 71 135 71C129 71 128 78 134 102L207 373C219 418 217 451 194 451C165 451 92 411 30 351L44 326C77 353 106 371 114 371C124 371 121 357 117 341L55 97C32 5 46 -12 70 -12C108 -12 191 51 227 95Z"></path></g></svg>,</span> before and after application of the coupling signal <span class="nowrap"><svg height="8.99888pt" id="M257" style="vertical-align:-3.18151pt" version="1.1" viewbox="-0.0498162 -5.81737 10.8789 8.99888" width="10.8789pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M219 86C216 168 211 250 206 337C201 410 189 448 163 448C131 448 79 396 43 344L60 322C91 359 110 375 118 375S132 358 136 298C141 238 152 81 155 -12H182C242 62 331 177 390 258C435 321 451 360 451 391C450 424 432 448 408 448C390 448 372 435 366 419C362 410 362 401 366 394C373 383 376 367 376 350C376 283 262 138 221 86H219Z"></path></g><g transform="matrix(.0091,0,0,-0.0091,5.811,3.132)"><path d="M389 0V32C297 38 291 46 291 118V635C234 613 175 595 109 583V556L161 554C203 552 207 547 207 497V118C207 46 201 38 110 32V0H389Z"></path></g></svg>.</span></div>

Complexity

fig11

Figure 11

Figure 11: Robust-Output-Controlled Synchronization Strategy for Arrays of Pancreatic <i>β</i>-Cells 

Complexity

Robust-Output-Controlled Synchronization Strategy for Arrays of Pancreatic β-Cells

Figure 11