Parameter Identification and Adaptive Control of Uncertain Goodwin Oscillator Networks with Disturbances

Figure 1

Scheme of a circadian oscillator modeled by a Goodwin oscillator. By the repression exerted by the inhibitor (c (t)) to the clock gene mRNA synthesis (a (t)), the three variables build up a closed negative feedback loop. The coupling from vasoactive intestinal polypeptide (VIP) is required to maintain circadian synchrony of the circadian oscillator.