Joint Nonnegative Matrix Factorization Based on Sparse and Graph Laplacian Regularization for Clustering and Co-Differential Expression Genes Analysis

Table 5

Co-DEGs identified by SG-jNMF on PAAD.

Name	Relevance score	Associated diseases	Related pathways
CDKN2A	91.19	Melanoma, cutaneous malignant 2, and melanoma-pancreatic cancer syndrome	Modulation and signaling and cell cycle role of SCF complex in cell cycle regulation
CCDN1	53.49	Multiple myeloma and Von Hippel–Lindau syndrome	ATF-2 transcription factor network and DNA damage response
PTF1A	33.66	Pancreatic and cerebellar agenesis and pancreatic agenesis 2	Developmental biology and regulation of beta-cell development
GRP	21.84	Duodenal ulcer and lung disease	Peptide ligand-binding receptors and signaling by GPCR