Analysis and Research of Key Genes in Gene Expression Network Based on Complex Network

Table 5

The biological significance of some key genes.

Gene	The significance of key genes
CDK13	Cyclin-dependent kinase (CDK) 12 and 13 are highly selective dual inhibitors that can inhibit triple-negative breast cancer (TNBC) cells. In terms of mechanism, the inhibition or loss of CDK12/CDK13 will cause the polyadenylation sites of introns to break, thereby inhibiting the expression of critical DNA damage response proteins. This causes the “BRCAness” phenotype, which leads to defects in DNA damage repair and promotes synergy with DNA-damaging chemotherapy and PARP inhibitors.
TPX2	TPX2 protein is highly expressed in breast cancer and has a certain correlation with the histological grade of breast cancer and lymph node metastasis. It may be a risk factor for the occurrence, development, and lymph node metastasis of breast cancer.
FOXM1	FOXM1 is considered as an emerging molecular target with its carcinogenic effect and 85% high overexpression characteristics in TNBC. FOXM1 occupies an important position in the gene network and is a key regulatory gene for breast cancer.