Research Article

The Adjustment of Covariates in Cox’s Model under Case-Cohort Design

Table 3

.

(%)Type
BiasSMSESDSECPBiasSMSESDSECP

1500.00160.08990.08990.09300.9610.01060.10320.10270.10840.968
0.00160.09000.09010.09200.963−0.11840.14900.09060.09540.759
0.00170.09030.09030.09290.9570.00140.10580.10580.10910.962
−0.00130.10100.10100.09990.9590.00790.11070.11040.11510.964
−0.00070.09910.09910.09890.961−0.11910.15320.09640.09980.728
−0.00110.10120.10120.09970.958−0.00520.11140.11130.11540.952
−0.00030.10780.10790.10830.9540.01230.12420.12360.12820.965
−0.00040.10830.10840.10740.946−0.12180.15760.10000.10760.772
−0.00030.10780.10790.10820.956−0.00020.12250.12250.12820.965
2000.00160.08070.08070.08230.9630.00730.09730.09710.09630.951
0.00290.07970.07960.08130.962−0.12390.14880.08240.08270.633
0.00170.08030.08040.08220.966−0.00180.09840.09850.09650.943
0.00070.08620.08630.08810.9620.00710.10240.10220.10360.953
0.00100.08450.08460.08730.960−0.12300.15150.08840.08780.672
0.00050.08650.08650.08810.965−0.00480.10320.10310.10370.948
0.00370.09400.09400.09860.9540.00910.11480.11450.11680.959
0.00440.09450.09440.09770.958−0.12700.15800.09410.09600.688
0.00340.09450.09450.09850.956−0.00360.11580.11580.11630.953
3000.00160.07060.07060.07030.9510.00120.08030.08040.08270.964
0.00100.07050.07060.06960.942−0.12940.14610.06790.06920.526
0.00190.07060.07060.07020.945−0.00810.08160.08130.08260.955
−0.00030.07670.07670.07610.947−0.00060.08680.08680.09080.960
0.00010.07650.07650.07560.947−0.13210.15040.07190.07450.545
−0.00020.07670.07670.07610.946−0.01110.08840.08780.09040.950
0.00070.08550.08550.08650.9600.00950.10460.10420.10540.954
0.00130.08450.08450.08610.969−0.12740.15210.08310.08370.638
0.00100.08560.08570.08650.959−0.00270.10380.10380.10400.950
1500.00050.10120.10130.10350.9570.00910.11440.11400.11950.953
0.00120.09980.09980.10240.959−0.11910.15700.10240.10570.755
0.00100.10070.10070.10340.9560.00200.11580.11580.12010.954
−0.00200.10590.10590.10940.9650.01320.12100.12030.12720.971
−0.00310.10480.10480.10800.965−0.11850.15900.10620.11090.798
−0.00200.10570.10580.10910.9650.00160.11980.11980.12790.966
−0.00380.11570.11570.11890.9620.00690.13760.13750.13890.957
−0.00400.11340.11340.11750.964−0.12690.16980.11280.11820.781
−0.00340.11600.11600.11870.959−0.00360.13870.13880.13930.955
2000.00420.09060.09050.09050.9440.01000.10570.10530.10610.962
0.00440.09030.09020.08920.944−0.11960.15090.09210.09240.696
0.00470.09040.09030.09030.942−0.00020.10500.10500.10650.956
−0.00180.09500.09500.09540.9620.00930.10890.10880.11240.962
−0.00160.09490.09500.09420.952−0.12580.15660.09330.09600.700
−0.00170.09440.09450.09520.957−0.00430.10920.10920.11250.958
−0.00010.10070.10080.10650.9720.01440.12380.12310.12630.965
0.00090.09910.09910.10540.968−0.12110.15870.10260.10550.763
0.00000.10040.10050.10640.9740.00260.12390.12390.12640.959
300−0.00100.07320.07320.07540.9590.00890.08770.08730.08900.965
−0.00110.07260.07260.07460.962−0.12160.14390.07690.07570.605
−0.00110.07330.07340.07540.960−0.00120.08790.08790.08910.965
0.00200.08100.08100.08130.9540.00530.09630.09620.09690.959
0.00110.08000.08000.08080.952−0.12750.15080.08070.08120.628
0.00150.08130.08130.08120.952−0.00530.09560.09550.09670.952
0.00440.09260.09260.09250.9530.01320.10920.10840.11180.961
0.00450.09230.09230.09190.954−0.12570.15300.08720.09060.687
0.00410.09220.09220.09240.9490.00130.10840.10850.11080.960

Note: denotes the estimator calculated based on the covariates without distorting factors, denotes the estimator calculated based on the covariates with distorting factors, and denotes the estimator calculate based on the adjusted covariates with distorting factors. Algorithm: MM algorithm.