Complexity

Research Article

Numerical Simulation of Thrombolysis in Robot-Assisted Retinal Vein Cannulation

Table 1

Nomenclature.
SymbolMeaningValueUnitReference
α0Amount of fibrin monomers per protofibril length0.0444nm−1[16]
DDispersion coefficient5 × 10−11M2s−1[17]
k2Michaelis–Menten reaction coefficient15s−1[16, 34]
kAPAntiplasmin reaction coefficient10μM−1s−1[24]
kads,PLGForward adsorption coefficient of PLG1.087 × 10−4μM−1s−1[27]
kads,PLSForward adsorption coefficient of PLS0.500 × 10−3μM−1s−1[27]
kads,tPAForward adsorption coefficient of tPA1.148 × 10−4μM−1s−1[27]
kcatLysis reaction rate coefficient10s−1[16]
kMMichaelis–Menten reaction coefficient0.13μM[16]
krev,PLGReversible adsorption coefficient of PLG4.131 × 10−3s−1[27]
krev,PLSReversible adsorption coefficient of PLS5.435 × 10−5s−1[27]
krev,tPAReversible adsorption coefficient of tPA6.658 × 10−5s−1[27]
LpfTotal length of protofibrils3mm—
NAVAvogadro's constant6.05 × 1023mol−1[17]
p0Amount of protofibril per fibre cross-sectional area0.01116nm−2[16]
Rf0Initial radius of fibrin fibre250nm[17]
ρfibreDensity of fibrin in fibre0.28gml−1[16]
ρβDensity of fibrin in clot0.003gml−1[17]
γAmount of cuts required by plasmin to cleave0.1—[16]
—One unit of fibrin———
r0Average radius of a protofibril2.39nm[16]