| | Factor | Single-factor change condition | Other fixed conditions |
| | Adjuvant ratio (marked as “A”) | 0.5 : 1, 1 : 1, 1.5 : 1, 2 : 1, 2.5 : 1 | Lactose and mannitol ratio = 1.5 : 1, ethanol concentration = 90%, ethanol dosage = 25% | | Lactose and mannitol ratio (marked as “B”) | 0.5 : 1, 1 : 1, 1.5 : 1, 2 : 1, 2.5 : 1 | Adjuvant ratio = 2 : 1, ethanol concentration = 90%, ethanol dosage = 25% | | Ethanol concentration of wetting agent (marked as “C”) | 60, 70, 80, 90, 95 | Lactose and mannitol ratio = 1.5 : 1, adjuvant ratio = 2 : 1, ethanol dosage = 25% | | Dosage of wetting agent (marked as “D,” %) | 10, 15, 20, 25, 30 | Lactose and mannitol ratio = 1.5 : 1, adjuvant ratio = 2 : 1, ethanol concentration = 90% |
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