Study on Preparation Technology and Physical Fingerprint of Chuilian Jianpi Granules Based on QbD

Table 3

Experimental design and results of response surface for granulation process.

Number	A	B	C (%)	Formability (%)	Hygroscopicity (%)	Angle of repose	Comprehensive scores (marked as “Y”)
1	1	0	1	94.35	4.05	25.1	95.15
2	0	1	−1	91.52	5.08	29.21	84.37
3	0	0	0	95.01	4.07	25.18	95.19
4	0	0	0	94.92	4.26	24.86	94.38
5	1	−1	0	86	4.71	28.77	84.18
6	0	0	0	95.13	4.28	24.63	94.64
7	0	−1	−1	94.11	5.15	29.73	84.67
8	0	0	0	88.04	3.54	29.31	91.96
9	0	1	1	98.71	4.62	31.59	87.37
10	0	0	0	96.54	4.26	25.72	94.00
11	−1	−1	0	86.89	5.33	25.68	85.14
12	1	1	0	96.73	4.57	26.01	92.06
13	−1	0	−1	94.21	5.01	30.62	84.53
14	−1	0	1	88.64	5.07	29.38	83.09
15	0	−1	1	89.41	4.61	29.65	85.25
16	−1	1	0	89.32	5.02	29.41	83.55
17	1	0	−1	89.93	4.61	29.79	85.34