Three Survival-Related Genes of Esophageal Squamous Cell Carcinoma Identified by Weighted Gene Coexpression Network Analysis

Figure 3

WGCN and their module-trait associations identified by the WGCNA. (a) Weighted gene coexpression network of ESCC identified 55 modules. A dendrogram was produced based on the WGCNA package in R by average linkage hierarchical clustering of 12,439 protein-coding genes. (b) Module-trait associations. Each column represents a module eigengene, and each row represents a clinical trait. Each cell contains the correlation coefficient (first line) and value (in parentheses). A value < 0.05 using Spearman’s correlation test was considered statistically significant. ESCC: esophageal squamous cell carcinoma; ME: module eigengene; TNM: tumor-node-metastasis; WGCN: weighted gene coexpression network; WGCNA: weighted gene coexpression network analysis.

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