Optimal Feedback Control of Cancer Chemotherapy Using Hamilton–Jacobi–Bellman Equation

Figure 4

Numerical simulations of tumor-immune model (1) with chemotherapy. The blue line means the feedback control and the green line represents the open-loop control. The upper panels indicate the number of effector cells for (a) and (b), respectively. The lower panels indicate the number of tumor cells for (c) and (d), respectively. The initial values are assumed to be .

(a)

(b)

(c)

(d)