Mechanisms of How Random Input Controls Bursting Gene Expression

Figure 2

The input signal induces dwell time drift with an activator. The first row represents the upstream input as noise, whereas the second row represents the difference in the dwell time between the noise and noiseless signals. (a) The OFF-state dwell time under the FM paradigm with the extracellular stimulus increasing its burst frequency or burst size; (b) the ON-state dwell time under the AM paradigm when the extracellular stimulus strength increases, and the means of the coloured lines are similar to (a). Other parameters are set as , , , , , , , and (as the standard of comparison).

(a)

(b)