Mechanisms of How Random Input Controls Bursting Gene Expression

Figure 3

The extracellular fluctuations make the dwell time drift with a repressor, and the first row represents the upstream input as noise, whereas the second row represents the difference in the dwell time between the noise and noiseless signal. (a) The OFF-state dwell time under the FM paradigm with the extracellular stimulus increasing its burst frequency or burst size; (b) the ON-state dwell time under the AM paradigm when the extracellular stimulus strength increases. The means of the coloured lines are similar to (a). The other parameters are the same as in Figure 2.

(a)

(b)