Mechanisms of How Random Input Controls Bursting Gene Expression

Figure 4

The mean burst frequency (a) and the noise (b) of downstream gene expression are under the FM paradigm, and the mean burst size of downstream gene expression is constant () when the strengthening extracellular stimulus increases and activates downstream gene expression. The red line represents the upstream stimulus signal as noiseless, and the green line represents the upstream stimulus signal as random with the burst frequency () changing and the burst size () being equal to 2, while the blue line represents the upstream stimulus signal as also random with the burst frequency () being equal to 2 and the burst size () changing. Other parameters are set as , , , , , and .

(a)

(b)