Labor Analgesia in Brugada Syndrome and the Importance of Contingency Planning

Table 2

Abbreviated list of medications and their safety profile for use in patients with Brugada syndrome.

Avoided or preferably avoided [37]	Drug-induced Brugada syndrome [38]	Potentially safe [39]
Antiemetics	Antihistamines	Antiemetics
Metoclopramide	Diphenhydramine	Dexamethasone [24]
Prochlorperazine	Terfenadine	Droperidol
		Ondansetron [24]
Antiarrhythmics	Miscellaneous	Analgesics
Flecainide	Alcohol	Ketorolac
Procainamid	Acetylcholine	Opioids
Propafenone	Cocaine
	Propofol [31, 40, 41]
Local anesthetics	Selective serotonin	Anesthetics
Bupivacaine	Reuptake inhibitors	Nitrous oxide
Lidocaine	Fluoxetine	Neuromuscular blockers
Procaine	Paroxetine	Reversal agents (e.g., Neostigmine/Glycopyrrolate, Sugammadex)
Miscellaneous		Thiopental Volatile agents (e.g., Desflurane, Isoflurane, Sevoflurane)
Cannabis		Volatile agents (e.g., Desflurane, Isoflurane, Sevoflurane)
Ketamine [32]
Oxcarbazepine
Tramadol
Psychotropics	Tricyclic antidepressants	Sedatives
Amitriptyline	Doxepin	Midazolam
Clomipramine	Imipramine
Lithium
Loxapine
Nortriptyline
Trifluoperazine
Uterotonics
Methylergonovine