Systemic Capillary Leak Syndrome: Is Methylene Blue the Silver Bullet?
Table 1
Time course of hemodynamic and laboratory parameters at baseline and during the second acute episode.
Time (hours)
BL
0
+5
+13.5
+24.5*
+36.5
+39.5
+47.5
+54.5
+61.5
+65.5
ABP (mmHg)
125/75
80/50
90/60
65/30
135/80
110/60
100/70
110/50
129/61
110/50
115/60
HR (1/min)
73
140
134
120
105
100
97
112
98
102
101
CVP (mmHg)
—
—
—
2/−3 (−1)
—
2/−3 (−1)
—
16/7 (12)
—
7/0 (4)
8/4 (6)
Hb (g/dL)
12.5
22.0
22.4
22.7
17.5
15.2
13.4
12
10.9
10.5
10.2
Ht (%)
37.1
67.1
68.2
69
53.4
46.5
41.2
36.9
33.5
32.3
31.5
Albumin (g/dL)
3.9
3.7
3.3
—
2.7
—
2.4
—
—
—
—
Creatinine (mg/dL)
1
1.2
0.9
1.2
1.5
1.2
pH
7.4
7.4
7.4
7.4
7.35
7.4
7.46
7.46
7.46
7.47
7.43
BE (mmol/L)
1.1
−2.8
−0.8
−4
−0.9
4.9
8.2
9.8
11.4
12.1
10.1
HCO3 (mmol/L)
26.4
22.9
24.2
22.6
24
29.6
32.4
34.3
36.1
36.6
35
Lactate (mmol/L)
0.6
1.6
1.7
2.2
2
1.3
1.6
1.2
1
1.1
1.3
Na (mEq/L)
141
134
134
131
137
139
141
142
143
143
143
K (mEq/L)
3.7
4.3
4.6
5.6
4.2
3.7
3.8
3.4
3.3
3.5
4.1
MetHb (%)
—
0.5
0.6
0.4
1.3
1.4
1.5
1.4
1.5
1.3
1.7
BL: baseline (3 months before the acute episode). First line refers to hours after admission. *Denotes methylene blue administration. ABP: arterial blood pressure; HR: heart rate; CVP: central venous pressure; Hb: haemoglobin; Ht: hematocrit; MetHb: methaemoglobin; BE: base excess; HCO3: bicarbonate; Na: sodium; K: potassium.
