Fatal Septic Shock in a Patient with Hemophagocytic Lymphohistiocytosis Associated with an Infectious Mononucleosis

Table 1

Diagnostic criteria of HLH.

Molecular diagnosis consistent with HLH.
Or 5 of the following criteria
(1) Fever
(2) Splenomegaly
(3) Cytopenia affecting 2 lineages
(a) Hemoglobin < 9g / dl
(b) Platelets < 90.000 / ml
(c) Neutrophils < 1000 /ml
(4) Hypertrigliceridemia and/or hypofibrinogemia
(a) Triglycerides > 265 mg/dl
(b) Fibrinogen < 150 mg/dl
(5) Hemophagocytosis in bone marrow, spleen or nodes
(6) Low/absent NK cell activity
(7) Ferritin ≥ 500 mcg/ml
(8) sCD25 (sIL2R) ≥ 2400U/ml