Simultaneous, Dual Continuous Venovenous Haemodiafiltration as Salvage Therapy for Severe Sodium Valproate Intoxication

Figure 1

Basic continuous venovenous haemodiafiltration (CVVHDF) configuration taken from East Kent Critical Care Guidelines. CRRT fluid was added to the circuit in three locations: prefilter replacement fluid (added to patients’ blood), dialysate (runs on the other side of the filter membrane to the patients’ blood), and postfilter replacement fluid (added to patients’ blood). The desired total effluent dose was calculated and then divided between dialysate and replacement fluid. Citrate was used for anticoagulation.