Simultaneous, Dual Continuous Venovenous Haemodiafiltration as Salvage Therapy for Severe Sodium Valproate Intoxication

Table 2

Settings for each continuous venovenous haemodiafiltration (CVVHDF) machine.

Dialysis parameters	CVVHDF 1	CVVHDF 2
Weight (kg)	60	—
BFR (ml/min)	150	100
PBP Cit (mmol/l)	3.0	3.0
PBP (ml/hr)	1500	100
Dia (ml/hr)	1500	900
Rep (ml/hr)	600	300
Ci load	14.7	10.2
Total effluent (ml/kg/hr)	60	36

BFR: blood flow rate (in ml/min); PBP Cit: concentration of citrate within the blood (mmol/l of blood); PBP: preblood pump (flow rate of citrate in ml/hr—calculated by machine when PBP Cit specified); Dia: dialysate flow rate (in ml/hr); Rep: postfilter replacement fluid (haemofiltration/convective part of RRT in ml/hr); Ci load: calculated citrate load (in mmol/hr) based on haematrocrit 30% (should be <30 mmol/hr).