A Case of Hepatotoxicity Induced by Therapeutic Ketamine Use for Sedation

Table 2

Naranjo adverse drug reaction probability scale.

Question	Answer	Score
(1) Are there previous conclusive reports on this reaction?	Yes	+1
(2) Did adverse events appear after the suspected drug was given?	Yes	+2
(3) Did the adverse reaction improve when the drug was discontinued or a specific antagonist was given?	Yes	+1
(4) Did the adverse reaction appear when the drug was readministered?	Not known or not done	0
(5) Are there alternative causes that could have caused the reaction?	No	+2
(6) Did the reaction reappear when a placebo was given?	Not known or not done	0
(7) Was the drug detected in any body fluid in toxic concentrations?	Not known or not done	0
(8) Was the reaction more severe when the dose was increased, or less severe when the dose was decreased?	Yes	+1
(9) Did the patient have a similar reaction to the same or similar drugs in any previous exposure?	Not known or not done	0
(10) Was the adverse event confirmed by any objective evidence?	Yes	+1

Total: 8 probable ADR. The reaction followed a reasonable temporal sequence after a drug, followed a recognized response to the suspected drug, was confirmed by withdrawal but not by exposure to the drug, and could not be reasonably explained by the known characteristics of the patient’s clinical state.