Case Report

An Uncommon Case of Plasma Cell Mucositis of the Tongue in a Young Man

Table 1

Review of PCM.

Study/year of publicationAgeGenderSymptomsLocation of the lesionsTreatmentFollow-up

Poswillo et al. [7]/196737FRedness, swellingGingivaResection, oral hygiene programmeAWD, 2 years
39FRedness, hypertrophyGingivaResectionNot available
21FHyperplastic red lesion, hypertrophy, erythemaMaxillary labial vestibule, gingivaResection, oral hygiene programmeNot available

White et al. [3]/198647FDysphonia, sore throatLips, mouth, tongue, supraglottic larynxResection, prednisoneAWD, 9 years (f/u reported by Ferreiro et al. [1])

Timms et al. [8]/198870FHoarseness, cough, stridorGingiva, supraglottic, hard palateCO2 laser, prednisolone, topical steroid sprayAWD, 1 year

Timms and Sloan [9]/199132FHoarseness, sore throatGingiva, false cord, mucobuccalSystemic and topical steroidsMarginal improvement, no f/u epiglottis

Ferreiro et al. [1]/199460FDysphonia, dysphagiaSupraglottic larynxCO2 laser, prednisone, antibiotics, beclomethasone (Vanceril) sprayAWD, 1 year
41MDysphonia, stridorSupraglottic, glottic larynx, nose, pharynxAntibioticsAWD, 7 years; tracheostomy
62FDysphonia, stridor, dry eyes, dysphagiaSupraglottic, glottic larynx, tracheaNot availableAWD, 16 years; tracheostomy
54MDysphoniaSupraglottic, glottic larynxResectionAWD, 1 year
40MDysphonia, sore mouthLips, tongue, palate, pharynx, supraglottic & glottic larynxPrednisone, isotretinoin (Accutane), CO2 laserAWD, 15 years; sleep apnea
67MSore mouthLips, mouth, tongue, palatePrednisoneAWD, 3 years
61MUnknownLips through larynxNot availableNot available
56MUnknownNose, palate, pharynxResectionNot available

Van de Kerkhof and Van Baar [26]/199580FPain, soreness, erythema, swellingLipsBetamethasone dipropionatePartial symptomatic relief, f/u not available
57FSore throatGingiva, supraglottic larynxTopical steroidsGingival improvement, no f/u

Khan et al. [5]/199769MHoarseness, dysphagia, hemoptysisLeft faucial pillar, hypopharynx, epiglottis, larynxBeclomethasone spray, Corsodyl mouthwashNo recurrence, 20 months f/u

Noorily [25]/199767MInduration, erythema, crustingLower lipResection, primary closureNot available

Smith et al. [4]/199959MSwelling, hoarseness, sore throat, erythemaSoft palate, gingiva, oropharynx, nasopharynxNoneAsymptomatic, 6 months f/u

Kaur et al. [24]/200147MSwelling, erythema, inflammationUpper lipTriamcinolone acetonide injectionsNo recurrence, 3 months f/u

Bharti and Smith [10]/200342FPain, dysphagiaBuccal mucosa, palateTopical and systemic antifungals, corticosteroidsPartial symptomatic relief, no regression of the disease, no f/u

Heinemann et al. [23]/200661FPain, ulcerations, erythema, erosionsTongue, lips, buccal mucosa, vulvaePrednisolone, cyclosporinComplete remission, 6 months f/u

Solomon et al. [2]/200860FPain, sore throat, erosions, swelling, erythemaGingiva, lips, ventral tongue, hard palatePrednisoneDisease remission, f/u not available

Senol et al. [11]/200846MInflammation, maceration, pruritic, eczemaOral commissures, gingivobuccal mucosa, toe-webs, groins, preputium, perineum, umbilicusPrednisoloneNo recurrence, 1 year f/u

Najarian et al. [12]/200856MPain, impetigo, bleedingLower lipTopical and systemic glucocorticosteroid, cryotherapyNo recurrence, 6 months f/u

Pepper et al. [13]/200977MAtrophy, hyperkeratosis, erosion, painCommissure, lips, cheekTacrolimus, methotrexate, betamethasone mouthwash, CO2 laser, radiotherapyOnset of squamous cell carcinoma, partial resolution of mucosal plasmacytosis

Puvanendran et al. [22]/201274MUlceration, erythemaUvula, hypopharyngeal wallResectionLesion resolved, 6 months f/u

Gupta et al. [21]/201472MDifficulty in swallowing, soreness, burning sensation, sore throat, ulcerations, swelling, bleeding gums, erosionsBuccal mucosa, palate, tongue, pharynx, gingivaTopical corticosteroids (betamethasone 1 mg, triamcinolone acetonide gel 0.1%), prednisolone, topical antifungalsPartial symptomatic relief, no regression of the disease, no f/u

Madhavarajan and Tighe [15]/201563MPain, ulcerationCommissure, buccal mucosa, gingivaNo treatmentSpontaneous resolving, 6 months f/u

Cottom et al. [20]/201554FErythemaSoft palateNot availableNot available
51MErythema, ulceration, erosionsBorder of tongueNot availableNot available
50MInflammationGingivaNot availableNot available
67MPain, bleeding, erosionsGingivaNot availableNot available
83FErosionsGingivaNot availableNot available
65MInflammationGingiva, hard palateNot availableNot available
72MInflammationGingivaNot availableNot available

Galvin et al. [14]/201668FErythema, ulcerationAlveolar ridges, palate, buccal mucosa, gingivaOral fluconazole, chlorhexidine mouthwash, betamethasone cream and tabletsAWD, 7 years
61FSore mouth, ulceration, erythema, edemaGingiva, buccal mucosaPrednisolone, adalimumabNo recurrence, 18 months
69MOropharynx congestionGingiva, dorsum and borders of the tongue, soft palate, uvulaMycophenolate mofetil, prednisolonePartial symptomatic relief, no regression of the disease, no f/u

Trehan et al. [19]/201639MUlceration, dysphagia, erosionsLips, buccal mucosa, gingivaPrednisoloneGood response, f/u not available

Arun et al. [17]/201713MSwelling, bleeding, erythema,Upper lip, gingivaTriamcinolone acetonide injections,No recurrence, 1 year f/u

Liu et al. [18]/201718FSwelling, bleeding, erosions, painLipsMethylprednisolone, dapsone, hydroxychloroquine, antibioticsSymptoms decreasing, 6 months f/u

Gasparro et al. [6]/201978FPain, erythema, ulcerations, erosionsBuccal mucosaInjectable platelet-rich fibrin (i-PRF)No complete healing, inflammation reduction, 6 months f/u

Shanahan et al. [16]/201962FDry mouth, ulceration, swelling, dysphagia, hoarsenessSoft palate, buccal mucosaPrednisolone, dapsone, mycophenolate mofetilNo recurrence of symptoms, 1 year f/u

AWD: alive with disease; F: female; f/u: follow-up; M: male. Age at presentation (years).