Ameloblastic Carcinoma with Calcification: A Rare Case Report in the Mandible and Literature Review

Figure 4

Histopathological features of ameloblastic carcinoma. (a) Ameloblastic carcinoma depicting the extensive area of calcified materials at the center of islands as well as in the intracellular areas (hematoxylin and eosin, ×40). (b) Follicles and islands with marked palisaded tall columnar cells at the periphery (hematoxylin and eosin, ×400). (c) Tumoral cells with pleomorphism, cellular atypia, loss of peripheral palisading, nuclear polarity, and presence of tumoral giant cell (hematoxylin and eosin, ×400). (d) Amorphous eosinophilic intercellular secretion which undergoes calcifications in some foci (hematoxylin and eosin, ×100). (e) Ki-67 immunostaining in ameloblastic carcinoma showed a significantly high Ki-67 labeling index especially at the periphery of the islands (×400).

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