MAML2-Rearranged Mucoepidermoid Carcinoma of the Parotid Gland: A Report in a 20-Month-Old Toddler

Figure 3

Histopathology of mucoepidermoid carcinoma of the parotid gland in a 20-month-old female patient. Morphology shows nests of epidermoid cells with nuclei appearing vesicular, pleomorphic, and hyperchromatic with an admixture of mucous cells and cystic spaces within a prominent connective tissue stroma (H&E ×200) (a, b), epidermoid cells positive for cytokeratin 7 (×200) (c), epidermoid cells positive for P63 (×200) (d), mucous cells positive for mucicarmine (×200) and (e) fluorescence in-situ hybridization for MAML2. Normal cells without translocation show two orange/green fusion signals. Cells with the translocation show one orange/green fusion and one orange and one green signal separate (representing a translocation of MAML2) (f).

(a)

(b)

(c)

(d)

(e)

(f)