Marine-Lenhart Syndrome: Case Report, Diagnosis, and Management

Table 1

Diagnosis of Marine-Lenhart syndrome in the literature: most recent to oldest.

Author; (Ref)	HT	TRAb/TSI	Thyroid ultrasound	Nodule on scan	Post-treatment scan	Pathology
[6]	+	+	Yes	H	Ye	PTC
	+	+	Yes	H	No	B
[7]	+	-	Yes	H	Ye	PTC
[8]	+	+	Yes	H/	Ye	PTC
[9]	SC	+	Yes		Yes	N/A
[10]	+	-	Yes	H	No	N/A
[11]			Ye		Yes	N/A
[12]	+	N/A	Yes	C	No	B
[13]	+	N/A	N/A	H	No	N/A
[14]	+	+	Yes	H	No	PTC
[15]	+	N/A	Yes	C	No	B
[16]	+	N/A	N/A	C	No	N/A
[17]	+	-	Yes		Yes	N/A
[18]	+	+	Yes	H	No	N/A
[19]	+	-	No	H	No	N/A
[20]	+	+	N/A	H	No	N/A
[21]	+	+	Yes	H	Yes	FTA
[22]	+	N/A	N/A		Yes	FTA

Abbreviations: B = benign pathology; C = cold; FTA = follicular thyroid adenoma; H = hot; HT = hyperthyroidism; N/A = not available; SC = subclinical; PTC = papillary thyroid carcinoma; TRAb = TSH receptor antibody; TSI = thyroid stimulating immunoglobulin.
body scan performed after treatment with radioactive iodine or surgery; uptake with centrally hypoactive foci before treatment; nodule detected post-treatment with radioactive iodine; was treated with radioactive iodine, achieved euthyroidism, and became negative for TRAb; a hot nodule was detected on follow-up on both ultrasound and nuclear scan; nodule before treatment and hot nodule after treatment with radioactive iodine.