Primary Aldosteronism Associated with Multiple Adrenocortical Micronodules in a Patient with Renal Cell Carcinoma

Figure 4

Histopathological findings of multiple micronodules and hyperplastic lesions in the left adrenal gland. (a) Hematoxylin and eosin staining. Multiple hyperplastic lesions in the left adrenal gland. Bar, 5 mm. (b) CYP11B2 immunostaining. Multiple CYP11B2-positive micronodules were detected predominantly at the subcapsular area of the adrenal cortex and showed preserved zonation. Many CYP11B2-negative hyperplastic cells were detected in the zona glomerulosa; paradoxical hyperplasia of the zona glomerulosa was noted. Bar, 5 mm. (c) CYP11B2 immunostaining. The magnified image of the CYP11B2-positive micronodules shown in (b). The CYP11B2 immunoreactivity waned from the subcapsular area to inward in the micronodules, in which zonation was preserved. Bar, 600 µm.

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