Simultaneous Coexistence of Thyrotropin-Prolactin-Secreting Adenoma and Papillary Thyroid Carcinoma

Table 3

The differential diagnosis markers between TSH-secreting adenomas (TSHomas) and resistance to thyroid hormones (RTH).

	TSHoma	RTH
Family history of thyroid disease	Absent	85%
Unsuppressed TSH or increased	Present	Present
Elevated thyroid hormone levels	Present	Present
Nycthemeral profile of TSH	Absent	Present
High levels of SHBG (TeBG)	Present	Absent
Increased α subunit	65%	3%
α-GSU/TSH molar ratio	>1%	<1%
Increase in TSH after a TRH	Negative	Positive
T3 suppression test	No TSH suppression	Suppression of TSH
Somatostatin test	FT4 ↓ >30%	FT4 is not affected
Multihormonal production	Possible	Absent
MRI pituitary	98%	10–20%
DNA mutation analysis	−	+