A Novel Microduplication in the Neurodevelopmental Gene SRGAP3 That Segregates with Psychotic Illness in the Family of a COS Proband

Figure 2

Predicted mRNA sequence and corresponding amino acid sequence generated using Sequencher 3.0. Exon 1 is shown in blue, and the tandem duplication of exons 2–4 is shown in pink. The duplication causes a frameshift which leads to six stop codons in the first 185 amino acids after the start of the duplication (represented by dots; see arrows). These data suggest that the transcript would not be functional.