Mitochondrial DNA Missense Mutations ChrMT: 8981A > G and ChrMT: 6268C > T Identified in a Caucasian Female with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Triggered by the Epstein–Barr Virus

<div>Chromosomes of mitochondria (ChrMT). Mitochondria in the cytoplasm of cells contain their own circular dsDNA (ChrMT). (a) ChrMT located outside of the nucleus. Offspring inherit ChrMT from their mothers. (b) Map of human ChrMT, derived from Shokolenko et al. [<a href="/journals/crig/2024/6475425/#B11">11</a>]. ND1-ND6 and ND4L encode subunits of CI; Cox1-Cox3 encode subunits of CIV; ATP6 and ATP8 encode subunits of CV; and cyt b encodes CIlI. The ChrMT encodes 13 proteins, composed of complexes of CI, CIV, CV, and CIII.</div>

Case Reports in Genetics

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Figure 1: Mitochondrial DNA Missense Mutations ChrMT: 8981A > G and ChrMT: 6268C > T Identified in a Caucasian Female with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Triggered by the Epstein–Barr Virus 

Figure 1 | Mitochondrial DNA Missense Mutations ChrMT: 8981A > G and ChrMT: 6268C > T Identified in a Caucasian Female with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Triggered by the Epstein–Barr Virus 