Case Report

Barrett’s Oesophagus in an Achalasia Patient: Immunological Analysis and Comparison with a Group of Achalasia Patients

Table 1

Analysis of peripheral blood and tissue immunophenotypes in the present case compared to 5 achalasia patients and 5 control subjects.

Healthy donors
()
Type II achalasia
()
Patient

⁢Blood
Peripheral blood immunophenotypes
CD3+/CD4+/CD161/IL-22+ (%)
  Mean ± SD1.95 ± 0.536.58 ± 2.567.72
  Median1.794.90
  Range1.39–2.552.79–16.70
CD3+/CD4+/CD161+/IL-17A+ (%)
  Mean ± SD1.96 ± 0.805.62 ± 1.735.42
  Median1.644.95
  Range1.40–3.352.72–12.30
CD3+/CD4+/CD25+/IL-4+ (%)
  Mean ± SD1.44 ± 0.653.23 ± 0.704.19
  Median1.363.76
  Range0.52–2.091.55–4.99
CD3+/CD4+/CD25+/IFN-γ+ (%)
  Mean ± SD1.76 ± 0.974.18 ± 1.313.6
  Median1.913.43
  Range0.29–2.872.15–9.30
CD3+/CD4+/CD25+/IFN-α+ (%)
  Mean ± SD2.26 ± 1.24.47 ± 0.855.08
  Median1.813.73
  Range1.31–4.352.11–6.80
CD3+/CD8+/CD28+/IFN-α+ (%)
  Mean ± SD3.05 ± 1.973.99 ± 0.475.87
  Median2.824.28
  Range1.48–6.392.54–5.27
CD3+/CD4+/CD25/Foxp3+ (%)
  Mean ± SD5.16 ± 0.787.21 ± 0.4510.1
  Median5.057.32
  Range4.00–6.035.64–8.35
CD3+/CD4+/CD25/IL-35+ (%)
  Mean ± SD3.60 ± 0.984.08 ± 0.449.96
  Median3.644.28
  Range2.50–5.112.39–4.88
CD3+/CD8+/CD28/Foxp3+ (%)
  Mean ± SD3.82 ± 0.715.39 ± 0.286.72
  Median3.955.46
  Range3.01–4.774.42–6.06
CD3+/CD8+/CD28/IL-35+ (%)
  Mean ± SD3.37 ± 0.774.53 ± 1.2812.4
  Median3.693.02
  Range2.19–4.012.12–9.09
CD3+/CD19+/CD38+/IL-10+ (%)
  Mean ± SD6.27 ± 1.076.99 ± 0.5814.1
  Median6.086.50
  Range5.07–7.814.88–8.09
CD3+/CD19+/CD38+/IL-35+ (%)
  Mean ± SD5.95 ± 0.454.31 ± 0.8919.2
  Median5.883.90
  Range5.58–6.702.20–7.60
CD123+/CD196+/IDO+ (%)
  Mean ± SD11.84 ± 1.3616.82 ± 1.6621.2
  Median11.5018.70
  Range10.30–14.0010.80–19.47

⁢Tissue
Tissue immunophenotypes
IL-22-expressing cells (%)
  Mean ± SD3.83 ± 1.8317.83 ± 1.4723.5
  Median4.0017.50
  Range2.00–7.0016.00–20.00
IL-17A-expressing CD4 T cells (%)
  Mean ± SD1.00 ± 0.688.33 ± 1.7517.00
  Median0.007.50
  Range0.00–4.007.00–11.00
IL-4-expressing CD4 T cells (%)
  Mean ± SD1.33 ± 0.336.33 ± 0.7514.00
  Median1.507.00
  Range0.00–2.004.00–9.00
IFN-γ-expressing CD4 T cells (%)
  Mean ± SD1.50 ± 0.6715.0 ± 1.2710.00
  Median1.0014.5
  Range0.00–4.0014.00–17.00
Foxp3-expressing CD25 T cells (%)
  Mean ± SD4.33 ± 0.337.83 ± 0.4811.50
  Median4.508.00
  Range3.00–5.006.00–9.00
IL-10-expressing CD20 B cells (%)
  Mean ± SD1.83 ± 1.315.33 ± 0.497.5
  Median2.005.50
  Range1.00–3.004.00–7.00
IDO-expressing CD123 cells (%)
  Mean ± SD3.67 ± 0.826.67 ± 0.338.5
  Median3.506.50
  Range3.00–5.006.00–8.00