Case Report
Barrett’s Oesophagus in an Achalasia Patient: Immunological Analysis and Comparison with a Group of Achalasia Patients
Table 1
Analysis of peripheral blood and tissue immunophenotypes in the present case compared to 5 achalasia patients and 5 control subjects.
| | Healthy donors () | Type II achalasia () | Patient |
| | Blood | Peripheral blood immunophenotypes | | | | CD3+/CD4+/CD161−/IL-22+ (%) | | | | Mean ± SD | 1.95 ± 0.53 | 6.58 ± 2.56 | 7.72 | Median | 1.79 | 4.90 | Range | 1.39–2.55 | 2.79–16.70 | CD3+/CD4+/CD161+/IL-17A+ (%) | | | | Mean ± SD | 1.96 ± 0.80 | 5.62 ± 1.73 | 5.42 | Median | 1.64 | 4.95 | Range | 1.40–3.35 | 2.72–12.30 | CD3+/CD4+/CD25+/IL-4+ (%) | | | | Mean ± SD | 1.44 ± 0.65 | 3.23 ± 0.70 | 4.19 | Median | 1.36 | 3.76 | Range | 0.52–2.09 | 1.55–4.99 | CD3+/CD4+/CD25+/IFN-γ+ (%) | | | | Mean ± SD | 1.76 ± 0.97 | 4.18 ± 1.31 | 3.6 | Median | 1.91 | 3.43 | Range | 0.29–2.87 | 2.15–9.30 | CD3+/CD4+/CD25+/IFN-α+ (%) | | | | Mean ± SD | 2.26 ± 1.2 | 4.47 ± 0.85 | 5.08 | Median | 1.81 | 3.73 | Range | 1.31–4.35 | 2.11–6.80 | CD3+/CD8+/CD28+/IFN-α+ (%) | | | | Mean ± SD | 3.05 ± 1.97 | 3.99 ± 0.47 | 5.87 | Median | 2.82 | 4.28 | Range | 1.48–6.39 | 2.54–5.27 | CD3+/CD4+/CD25/Foxp3+ (%) | | | | Mean ± SD | 5.16 ± 0.78 | 7.21 ± 0.45 | 10.1 | Median | 5.05 | 7.32 | Range | 4.00–6.03 | 5.64–8.35 | CD3+/CD4+/CD25/IL-35+ (%) | | | | Mean ± SD | 3.60 ± 0.98 | 4.08 ± 0.44 | 9.96 | Median | 3.64 | 4.28 | Range | 2.50–5.11 | 2.39–4.88 | CD3+/CD8+/CD28−/Foxp3+ (%) | | | | Mean ± SD | 3.82 ± 0.71 | 5.39 ± 0.28 | 6.72 | Median | 3.95 | 5.46 | Range | 3.01–4.77 | 4.42–6.06 | CD3+/CD8+/CD28−/IL-35+ (%) | | | | Mean ± SD | 3.37 ± 0.77 | 4.53 ± 1.28 | 12.4 | Median | 3.69 | 3.02 | Range | 2.19–4.01 | 2.12–9.09 | CD3+/CD19+/CD38+/IL-10+ (%) | | | | Mean ± SD | 6.27 ± 1.07 | 6.99 ± 0.58 | 14.1 | Median | 6.08 | 6.50 | Range | 5.07–7.81 | 4.88–8.09 | CD3+/CD19+/CD38+/IL-35+ (%) | | | | Mean ± SD | 5.95 ± 0.45 | 4.31 ± 0.89 | 19.2 | Median | 5.88 | 3.90 | Range | 5.58–6.70 | 2.20–7.60 | CD123+/CD196+/IDO+ (%) | | | | Mean ± SD | 11.84 ± 1.36 | 16.82 ± 1.66 | 21.2 | Median | 11.50 | 18.70 | Range | 10.30–14.00 | 10.80–19.47 |
| | Tissue | Tissue immunophenotypes | | | | IL-22-expressing cells (%) | | | | Mean ± SD | 3.83 ± 1.83 | 17.83 ± 1.47 | 23.5 | Median | 4.00 | 17.50 | Range | 2.00–7.00 | 16.00–20.00 | IL-17A-expressing CD4 T cells (%) | | | | Mean ± SD | 1.00 ± 0.68 | 8.33 ± 1.75 | 17.00 | Median | 0.00 | 7.50 | Range | 0.00–4.00 | 7.00–11.00 | IL-4-expressing CD4 T cells (%) | | | | Mean ± SD | 1.33 ± 0.33 | 6.33 ± 0.75 | 14.00 | Median | 1.50 | 7.00 | Range | 0.00–2.00 | 4.00–9.00 | IFN-γ-expressing CD4 T cells (%) | | | | Mean ± SD | 1.50 ± 0.67 | 15.0 ± 1.27 | 10.00 | Median | 1.00 | 14.5 | Range | 0.00–4.00 | 14.00–17.00 | Foxp3-expressing CD25 T cells (%) | | | | Mean ± SD | 4.33 ± 0.33 | 7.83 ± 0.48 | 11.50 | Median | 4.50 | 8.00 | Range | 3.00–5.00 | 6.00–9.00 | IL-10-expressing CD20 B cells (%) | | | | Mean ± SD | 1.83 ± 1.31 | 5.33 ± 0.49 | 7.5 | Median | 2.00 | 5.50 | Range | 1.00–3.00 | 4.00–7.00 | IDO-expressing CD123 cells (%) | | | | Mean ± SD | 3.67 ± 0.82 | 6.67 ± 0.33 | 8.5 | Median | 3.50 | 6.50 | Range | 3.00–5.00 | 6.00–8.00 |
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