Ulcerative Colitis in Hematological Malignancies: Paraneoplastic Manifestation or Coincidental Bystander?

Table. 1

Laboratory parameters recorded in each patient

	Case 1	Case 2	Case 3
WBC	9500/μL	Pre-t 2580/μL	12000/μL
		Post-t 3500/μL
Hct	35%	Pre-t 22.9%	36.6%
		Post-t 26.7%
Plt	WNR	Pre-t 138000/μL	452000/μL
		Post-t 226000/μL
Reticulocyte count	WNR	Pre-t 0.02 × 10^6	WNR
		Post-t 0.028 × 10^6
ESR (mm)	40	78	38
CRP (mg/dL)	9	13	1.3
IgG (mg/dL)	WNR	WNR	1890
IgA (mg/dL)	WNR	385	363
ASCA (U/mL)	—	62.2 (IgG)	—
	20.9 U/mL (IgA)	38.1 (IgA)	—
ANCA	—	1 : 40 (a-ANCA)	1 : 320 (c-ANCA)
Anti-EBV	+ (IgG)	+ (IgG)	+ (IgG)
Anti-CMV	+ (IgG)	+ (IgG)	+ (IgG)
Anti-VZV	+ (IgG)	+ (IgG)	+ (IgG)
Anti-HSV-1	+ (IgG)	+ (IgG)	+ (IgG)
HLA typing	B35, B55	B51, B55	B07, B35
Cultures (blood/fecal)	Negative	Negative	Negative
Additional	High avidity	Coombs (−)	High avidity
		Anti-platelet antibodies (−)
Endoscopy	Continuous pattern involvement of all colonic segments’ friability, petechial bleeding, edema, and granularity	Continuous pattern involvement of all colonic segments’ mucous friability, petechial bleeding, oedema, and granularity	Similar to case 2
Histopathology	Crypt atrophy, crypt abscesses, and LP mononuclear cell infiltration	Similar to case 1	Similar to cases 1, 2

WBC: white blood cell; Hct: hematocrit; Plt: platelet; t: treatment; ESR: erythrocyte sedimentation rate; CRP: C-reactive protein; Ig: immunoglobulin; ASCA: anti-Saccharomyces cerevisiae antibodies; ANCA: anti-neutrophil cytoplasm antibodies; EBV: Epstein–Barr; CMV: cytomegalovirus; HSV-1: herpes simplex virus-1; VZV: varicella-zoster virus; HLA: human leukocyte antigen; WNR: within normal range; LP: lamina propria.