Gastrointestinal Stromal Tumours (GISTs) with KRAS Mutation: A Rare but Important Subset of GISTs

Table 2

KRAS-mutated GIST.

References	Age/gender	Site	KRAS mutation	KIT IHC	DOG1 IHC	SDH IHC	Histology
Miranda et al. [13]	NM	Gastric	G12D	NM	NM	NM	NM
Miranda et al. [13]	NM	Small bowel	G13D	NM	NM	NM	NM
Miranda et al. [13]	NM	Gastric	G12A/G13D	NM	NM	NM	NM
Antonescu et al. [14]	66/male	Small bowel	G12V	Neg	NM	NM	Anaplastic
Serrano et al. [15]	61/male	Gastric	G12R	Pos	NM	NM	Spindle
Hechtman et al. [16]	67/male	Gastric	G12V	Pos	NM	Lost	Pleomorphic epithelioid
Gao et al. [17]	NM	NM	G13D	NM	NM	NM	NM
Mavroeidas et al. [18]	NM/male	Gastric	G12D	NM	NM	NM	Spindle
Current case 1	77/female	Small bowel	G12D	Pos	Pos	Retained	Pleomorphic spindle
Current case 2	50/female	Small bowel	G13D	Pos	Pos	Retained	Epithelioid and spindle

IHC = immunohistochemistry; Pos = positive; Neg = negative; NM = not mentioned;  = with concomitant KIT mutation;  = with concomitant PDGFRA mutation.