Acute Lymphoblastic Leukemia Arising in CALR Mutated Essential Thrombocythemia

Figure 1

(a) Bone marrow trephine biopsy at diagnosis of essential thrombocythemia (Hematoxylin and Eosin; magnification ×20); (b) fragment length detection of the CALR mutation; (c) bone marrow aspirate at diagnosis of acute lymphoblastic leukemia; (d) bone marrow trephine biopsy following two courses of chemotherapy (Hematoxylin and Eosin; magnification ×20); (e) mutant CALR allele burdens.

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