A Rare Case of Erdheim-Chester Disease (Non-Langerhans Cell Histiocytosis) with Concurrent Langerhans Cell Histiocytosis: A Diagnostic and Therapeutic Challenge

<div>Representative sections of Langerhans cell histiocytosis. (a) Low-power (20x) image demonstrates a diffusive cellular infiltrate with prominent eosinophils. (b) High-power (100x) image demonstrates populations of eosinophils, macrophages with foamy cytoplasm, and large, variably elongated spindled cells with indented, grooved nuclei and eosinophilic granular cytoplasm. These cells are diffusely positive for (d) S100 and (e) CD1a and (c) focally positive for CD68, consistent with Langerhans cells.</div>

Case Reports in Hematology

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Figure 5: A Rare Case of Erdheim-Chester Disease (Non-Langerhans Cell Histiocytosis) with Concurrent Langerhans Cell Histiocytosis: A Diagnostic and Therapeutic Challenge 

Figure 5 | A Rare Case of Erdheim-Chester Disease (Non-Langerhans Cell Histiocytosis) with Concurrent Langerhans Cell Histiocytosis: A Diagnostic and Therapeutic Challenge 