Simultaneous Occurrence of Rosai–Dorfman Disease and Nodal Marginal Zone Lymphoma in a Patient with Sjögren’s Syndrome

Figure 1

(a) The lymph node shows a completely effaced architecture. The sinus system is open and filled with partly pleomorphic histiocytic cells (×50, hematoxylin and eosin stain (H&E)). (b) The partly pleomorphic histiocytic cells are present in the sinuses, while the intervening cords exhibit a marked plasmacytosis (×200, H&E). (c) The histiocytic cells express CD68 (×200). (d) The histiocytic cells show nuclear and cytoplasmic positivity for S100 (×200). (e) The mature plasma cells (Marschalko type) present in the intervening cords (×630, H&E). (f) Monomorphic expression of light kappa chain in plasma cells (×630). (g) Monomorphic expression of IgM in plasma cells (×630). (h) Expression of MUM1 in plasma cells (×630). (i) Ki-67 is expressed in 5–7% of the cells of the sinuses and up to 50% of cells within the intervening cords of the lymph node (×200).

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