Prefibrotic Myelofibrosis Presenting with Multiple Cerebral Embolic Infarcts and the Rare MPL W515S Mutation

Figure 1

(a) Bone marrow biopsy demonstrating megakaryocyte clustering with nuclear hypolobation and bulbous forms; (b) next-generation sequence analysis (Sequence Pilot, JSI Medical Systems, Ettenheim, Germany) identifying MPL p.W515S (c.1544G > C).

(a)

(b)