Pulmonary Lymphangitic Spread of Multiple Myeloma as Early Relapse after Autologous Stem Cell Transplantation

Figure 1

(a) Coronal sections of computed tomography showing worsening of bilateral lower lobe consolidation along with extensive ground-glass density, interlobular septal thickening. (b) Pathological specimen showing infiltration of lung parenchyma by kappa light chain restricted atypical plasma cells with a large, round to irregular nuclei, variably prominent nucleoli, and moderate amounts of eosinophilic cytoplasm. Flow cytometry showed 17.9% plasma cells with the following immunophenotypic markers (CD5 (−), CD10 (−), CD19 (−), CD20 (−), CD38 (bright+), CD45 (dim+), CD56 (partial dim+), CD138 (variably+), and CD319 (+)) (Hematoxylin and eosin; 20x, 100x, 500x, and 500x, respectively.)

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