Intrasinusoidal Hodgkin Lymphoma; A Mimic of Anaplastic Large Cell Lymphoma

Table 1

Immunophenotypic and genetic studies.

Anaplastic large cell lymphoma	Classic Hodgkin lymphoma
Immunophenotype
T/null	T-cell (rare 5%)
CD15−/+ (0–20%)	CD15+ (75%)
PAX5 −	PAX5 weakly + (90%)
CD45 usually +	CD45 usually −
EMA + (60–100%)	EMA – (rarely + 0–5%)
CD43 +	CD43 usually −
IFR/MUM −	IFR/MUM +
ALK 1 may be + in some cases	ALK 1 −
EBER + (5–20%)	EBER + (15–75%)
Genetic studies
T-cell receptor gene rearranged
t(2,5)-NPM/ALK rearrangement