NGS Analysis of Clonality and Minimal Residual Disease in a Patient with Concurrent Richter’s Transformation and CLL/SLL

Figure 1

Tumor histology and V-J frequency graphs. On the left are H&E sections from the DLBCL in the lymph node and CLL/SLL in the bone marrow. Inset: high-power view of the DLBCL in the lymph node. On the right are the -J frequency graphs from FR3-J primers showing the clonal and LQ reads. The Y-axis is the % of total reads, and X-axis is the specific -J rearrangement. Clonal reads are present in both the lymph node and bone marrow. C: clonal, V1-202/D5-1201/J402, LQ: LymphoQuant control, and V1-6901/D6-1301/J603.