Chronic Eosinophilic Leukemia Presenting as Cardiac Failure

Figure 3

Bone marrow aspirate morphology and FISH result: (a) Bone marrow aspirate showing (i) eosinophilic myelocyte (ii) eosinophilic metamyelocyte (iii) eosinophilic band (iv) normoblast (b) FISH signal pattern at diagnosis indicative of deletion of CHIC2 gene. FISH signal patterns in nuclei having interstitial deletions of the orange probe target (CHIC2) should be observed as one tri-colour fusion and one green/aqua fusion. (c) FISH signal pattern 3 months post imatinib showing no evidence of CHIC2 deletion.

(a)

(b)

(c)